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Core Team
Ben Collins Ben Collins
Group Leader
Ben is the Professor of Proteomics and Chemical Biology in the School of Biological Sciences at Queen’s University Belfast, UK. His research focuses on broadly on 3 topics: (i) method development and applications in data independent acquisition mass spectrometry; (ii) analysis of protein interaction networks and protein complexes; and (iii) applications of these strategies in drug discovery, innate immunity, host-pathogen biology, and cancer biology. Ben’s PhD was completed at University College Dublin in 2009 where he remained for 1 year as the Agilent Technologies Newman Fellow. Ben moved to the Institute of Molecular Systems Biology at ETH Zurich in Autumn 2010 as postdoctoral researcher in the pioneering group of Prof. Ruedi Aebersold, where his research focused on the application of quantitative interaction proteomics in signaling and the development of DIA mass spectrometry. Following this Ben was a Group Leader and SNF Ambizione Fellow at ETH Zurich before moving to moving to Belfast in 2019 to set up an independent group. In 2020 Ben won the HUPO Discovery in Proteomic Sciences Award for contributions to DIA mass spectrometry. He currently co-directs the NI Centre of Excellence for Chemoproteomics.
Mohammad Arefian Mohammad Arefian
Postdoctoral Research Associate
I obtained my Ph.D. from Ferdowsi University of Mashhad, Iran in 2018; wherein I evaluated the effect of salinity stress on plants at physiological, gene expression, and proteome levels. I continued my research as a Postdoctoral Fellow at Yenepoya research center in India, where my research mostly focused on kinase-mediated signaling pathways (de)activated in rice and Arabidopsis upon stress and during flowering. Besides post-translational modifications, my researches were also involved proteomic, proteogenomic, and metabolomic approaches to investigate cancers and infectious diseases in human, as well as stress-responsive mechanisms in model plants.
Chinmaya Narayana Chinmaya Narayana
Postdoctoral Research Associate
Chinmaya is a mass spectrometry enthusiast with over seven years of experience working with various LC-MS systems. His journey with mass spectrometry began at Aurigene Discovery Technologies in Hyderabad, where he spent nearly two years as a research associate in the drug metabolism and pharmacokinetics team. He then pursued his Ph.D. at Yenepoya Research Centre, Yenepoya University in Mangaluru, India, focusing on developing a mass spectrometry-based species-specific spectral library for non-tuberculous mycobacteria under the guidance of Prof. T. S. Keshava Prasad. Upon completing his Ph.D., he joined the Collins Lab at the School of Biological Sciences, Queen’s University Belfast, as a post-doctoral research fellow. Chinmaya’s technical expertise includes handling and maintaining various LC-MS systems, as well as developing and optimizing methods such as PRM, MRM, DIA, and DDA for peptides, small molecules, and intact proteins.
Jack Penny Jack Penny
PhD Student
Project: A map of host cell rewiring by pathogens. Jack is a PhD student investigating host cell rewiring by pathogens with a particular interest in the ubiquitin system. Jack completed his undergraduate degree in Biochemistry and Master of Research at Aberystwyth University in 2018. His previous projects involved metabolomics and natural product drug discovery with an interest in antimicrobials and overcoming resistance mechanisms. Co-supervisors Gunnar Schroeder and José Bengoechea
Emma Mckay Emma Mckay
PhD Student
Project: Protein complex dynamics in innate immunity. Emma is a PhD student investigating the dynamics of protein interactions and post translational modifications in the NLRP3 inflammasome system, a central signalling hub of the innate immune system. Emma completed her undergraduate degree in Biological Sciences at Queens University Belfast, graduating in 2021. Co-supervisor Rebecca Coll
Dino Rocca Dino Rocca
PhD Student
Project: Regulation of Inflammasome Function by the Ubiquitin System. Dino received his degree in Biotechnology from the University of Galway. During this time, he carried out a seven-month research placement at Leiden University Medical Centre in the Netherlands, where he investigated the pathogenic and non-pathogenic effects of protein aggregation in OPMD cell models. For his final year project, he conducted another research placement at the Centre for Chromosome Biology Galway where he utilised shRNA technology to down regulate proteins of interest related to CDC7 and DNA replication. Dino’s PhD will investigate the regulation of inflammasome function by the ubiquitin system. Co-supervisors Helen Walden and Rebecca Coll
Knox Wilson Knox Wilson
PhD Student
Project: Advanced Mass Spectrometry to Expand the Chemical Proteomics Toolset. Starting Oct 2024. Co-supervisor Dan Longley and Rich Williams
Thomas McConnell Thomas McConnell
PhD Student
Project: New Chemoproteomics Tools for Drug Discovery in Inflammation. Starting Oct 2024. Co-supervisor Rebecca Coll
Niamh Mallon Niamh Mallon
Msci Student
Project: Characterizing small molecule induced protein-proteins by affinity purfication-mass spectrometry Starting Oct 2024
Co-Supervision
Simran Cheema
PhD Student
Project: Maximizing the clinical impact of Human Milk on Prevention of Necrotizing Enterocolitis. Co-supervised with Simon Cameron and Natalie Shenkar
Daniel Lockwood
PhD Student
Subversion of innate immune defences by intracellular bacterial pathogens. Co-supervised with Gunnar Schroeder and Miguel Valvano
Prachi Bendale
PhD Student
Novel Molecular Tools to Tackle the Antimicrobial Resistance (AMR) Emergency. Co-supervised with Gerd Wagner and Miguel Valvano
Alumni
Charlotte Nicod
PhD graduated 2020 (ETH Zurich)
Unraveling host-pathogen interactions upon Mycobacterium tuberculosis infections using quantitative mass spectrometry. Now Associate at Flagship Pioneering.
Amir Banaei-Esfahani
PhD graduated 2019 (ETH Zurich)
Deconvolution of Biochemical Pathways in Genetically Diverse Mycobacterium tuberculosis. Now Senior Bioinformatics Scientist at Universitätsspital Zürich.
Shruti Jha
Research Assistent 2017-2019 (ETH Zurich)
Host-pathogen interactions upon Mycobacterium tuberculosis infections. Now Research Associate at DewPoint Therapeutics.
Project Students
Ellie Schevlin
BSc Student 2024
Proteome analysis of macrophages infected with Mycobacterium tubercolosis RD1 mutant.
Knox Wilson
BSc Student 2024
Assembly of a p97 cofactor protein-protein interaction network from affinity purification mass spectrometry data.
Sophia Kennedy
BSc Student 2024
Novel post translational modifications in the 14-3-3 signalling system.
Jie Ma
MSc Student 2023
Analysis of Protein Complex Alterations of Immune System in using SEC-SWATH Mass Spectrometry.
Ciaran Purdy
BSc Student 2023
Proteome analysis of macrophages infected with Mycobacterium tuberculosis RD1 mutant.
Abbie McDougall
BSc Student 2023
Identifying Novel Post Translational Modifications in Blood Plasma Proteins.
Meaghan King
MSc Student 2022
Assembly of a Mycobacterium tuberculosis host-pathogen protein-protein interaction network.
Olivia Mulderrig
BSc Student 2022
Novel post translational modifications in cardiomyopathy.
Daniel Cosby
BSc Student 2022
Novel post translational modifications in the VCP/p97 signalling system.
Katie Marshall
BSc Student 2022
Epitope mapping of cell surface proteins of Mycobacterium tuberculosis complex organisms.
Cansu Uygun
MSc Student 2021
Mass spectrometry based proteomics – longitudinal evaluation and quality control of analytical methods.
Noemi Casaferniza Ochoa
MSc Student 2021
Novel post translational modifications in the interactome of 14-3-3β.
Clare-Ann Nelson
BSc Student 2021
Novel Post Translational Modifications in the Macrophage Proteins Targeted by Mycobacterium tuberculosis.
Emily Lecky
BSc Student 2021
Quantitative Aspects of Ion Mobility – Mass Spectrometry in Proteomics.
Megan Taylor
BSc Student 2021
Proteome analysis of macrophages infected with Mycobacterium tuberculosis RD1 mutant.
Caolán Doran
MSc Student 2020
Assembly of a p97 cofactor protein-protein interaction network.
Jun Cai
MSc 2018 (ETH Zurich)
Elucidating Host-Pathogen Protein-Protein Interactions in the Context of Mycobacterium Tuberculosis Infections.